稳定型含氯消毒剂的稳定性研究

目的研究稳定型含氯消毒剂存放过程中的稳定性。方法在半开放与封闭条件下，对有效氯浓度介于60～15000mg／L的稳定型含氯消毒剂进行长达590d的保存实验，并对其主要指标与消毒性能进行监测。结果保存条件与有效氯浓度对稳定型含氯消毒剂的稳定性有明显影响，较高含量的有效氯浓度与封闭保存条件可获得较长的保存期；在保存过程中稳定性含氯消毒剂的消毒能力略降，主要与其有效氯的衰减有关。结论在封闭保存条件下，稳定型含氯消毒剂的保存期可长达1年，并保持较强的消毒能力，具有实际使用价值。     

我院药库药品贮藏温度的调查分析

目的:为药品保管工作提供参考。方法:对我院药库所有药品说明书中贮藏项下有温度要求的药品进行分类调查分析。结果:库存药品1254种,贮藏项下有温度要求的483种(38.52%),在常温贮藏注明具体温度的158种,在冷处贮藏注明温度的61种。结论:药品在贮藏时要根据其不同性质选择适当的温度,从而保证药品质量的稳定性,建议药品说明书中贮藏项下最好注明具体温度。     

初均速法预测银黄口服液的贮存期

采用初均速温度加速实验法预测银黄口服液贮存期,其中有效成分绿原酸和黄芩甙的含量测定采用《中国药典》“银黄口服液含量测定”项下进行。口服液中两种有效成分的降解均符合Arrhenius指数规律;测得绿原贮存期为4.73年,黄芩甙贮存期为4年。本口服液贮存期可暂定为4年。     

Iodine losses in iodised salt following different storage methods

Iodine retention in three types of iodised salt viz., powdered salt, white crystal and brown crystal salt was estimated at an interval of 15 days following commonly practised storage methods i.e., glass jar with lid, plastic jar with lid, earthernware pot with lid, cut open salt packet and salt pack as it is. Highest percent retention of iodine irrespective of type of salt was noticed in intact salt packet (97.19%). The iodine retention was above 80% in other methods—88.41% retention in cut open salt packet, 84.72% in glass jar, 82.86% in earthern pot and 80.85% in plastic jar. Powdered salt had maximum iodine retention (91.16%) followed by brown crystal salt (84.24%) and white crystal salt (76.71%). Even though the iodine content was found to decrease during storage, the powdered salt and brown crystal salt had iodine in the recommended level. On the contrary, white crystal salt contained only half (7 ppm) that recommended at the retail level (15 ppm).     

PubMed与MEDLINE光盘检索不同之处的特点探讨

目的：探讨PubMed检索的主要特点以提高文献的查准率。方法：分别举例介绍PubMed数据时限、超级主题词表、查询词自动转换、主题词检索、临床课题查询、Entrez—PubMed、PubMed Central(PMC)。结果：PubMed检索,除MEDLINE外,还包括PREMEDLINE和OLDMEDLINE,其最早的文献可追溯到1951年。通过查询词转换和匹配及其临床课题研究范围的灵敏度和专指度的选择,使检出的文献更加切题。PubMed还通过与全球NCBI搜索引擎Entrez链接,可互查PMC、核酸序列、蛋白质序列、大分子结构、全基因组、生物体分类学、人类盂德尔遗传及MEDLINE数据库等。检出的记录包括文献条目和摘要,链接后可获取出版商网址上的全文及其在PMC中的免费期刊(160种)原文。结论：PubMed为一般的医学工作者检索文献提供的服务比MEDLINE光盘要多。     

Influence of age, postmortem delay and freezing storage period on cannabinoid receptor density and functionality in human brain

It has been suggested that cannabimimetic drugs could be of interest in the treatment of several nervous disorders. Thus, it is important to analyse the distribution and properties of cannabinoid (CB) receptors directly in human brain. As postmortem human tissue is subjected to the effects of several biological variables, we have analyzed by autoradiography the influence of age, postmortem delay and freezing storage period (at -25 degrees C) on two parameters corresponding to cannabinoid CB1 receptors in human frontal cortex: receptor density and degree of activation of G-proteins ([35S]GTPgammaS assays). A significant decrease in the amount of both receptor density and agonist-stimulated G-protein activity was observed with age, revealing a mean reduction of about 10% per decade. In contrast, no significant correlations were found with postmortem delay either for CB1 receptors density or functionality. Finally, both parameters (receptor density and [35S]GTPgammaS response) were significantly reduced with freezing storage period at -25 degrees C in frontal cortical layers. Non-linear analysis of these data yielded values between 12 and 24 months of storage for a 50% reduction. In conclusion, when studying CB1 receptor properties in human brain samples, a careful analysis (and matching) for variables such as age and freezing storage period has to be carried out.     

Storage phosphor and film-screen mammography: performance with different mammographic techniques

The aim of this study was to compare the image quality of storage phosphor plates with that in screen-film radiograms in mammography. Two anode/filter combinations were also compared – Mo/Mo and W/Rh. S Storage phosphor plates, generation IIIN (Fuji, Tokyo, Japan) and a conventional screen-film system (Kodak, Rochester, N. Y.) were evaluated using two mammographic units. One unit had a 0.6-mm focal spot, an anode/filter combination of Mo/Mo and no grid (A_Mo); the other had a 0.3-mm focal spot, a grid, and two possible combinations of anode/filter Mo/Mo (B_Mo) and W/Rh (B_W). Simulated tumours and microcalcifications were randomly positioned in an anthropomorphic breast phantom (RMI model 165, no. 210–009, Radiation Measurements Inc., Middleton, Wisconsin). The image quality was evaluated using a modified version of receiver operating characteristics analysis. Five observers evaluated 300 films and 300 hard copy images each. Radiation doses were also determined. The image quality of the conventional screen-film images was significantly better than that for the storage phosphor plate mammograms. The B_Mo system rated best, for the detection of both tumours and microcalcifications, although it was not significantly different from the B_W system. Systems B_Mo and B_W rated significantly better than the A_Mo system for both image receptors studied. The mean absorbed dose was twice as high for the B_Mo system as for the A_Mo and B_W systems for both conventional and digital technique. The mammograms produced with the screen-film combination gave a significantly better detectability than the storage phosphor plates used in this study. Substantial dose reduction could be achieved using an anode/filter combination of W/Rh instead of Mo/Mo with no significant loss of information in the images. Received 6 June 1997; Revision received 22 August 1997; Accepted 10 July 1998     

储存磷光质屏放射自显影在测定兔血浆中^125I—重组人尿激酶原浓度的应用

目的　探讨储存磷光质屏放射自显影结合聚丙烯酰胺凝胶电泳测定兔血中12 5I 重组人尿激酶原 (12 5I rhpro UK)浓度的方法。方法　将含12 5I rhpro UK样品的聚丙烯酰胺凝胶贴于储存磷光质屏上曝光 ,根据储存磷光质屏上检出的吸收度值计算12 5I rhpro UK浓度。结果与结论　该方法特异性、线性及线性范围、灵敏度、重现性、回收率均可达到蛋白多肽药物药代动力学研究的要求。并测定了 0 .8mg·kg-1静脉给药时 (12 5I rhpro UK/rhpro UK =1∶9混合 ) ,兔血浆12 5I rhpro UK浓度 -时间曲线     

Postauricular cartilage storage in rhinoplasty

In the past decade, the number of patients demanding rhinoplasty has increased, and this has increased the use of grafts. Although different materials are used as grafts, cartilage is the most popular one. In secondary rhinoplasties the need for cartilage is very frequent. The most suitable cartilage grafts are the ones extracted during primary rhinoplasty. These grafts are disposed of after the operation and in a secondary operation, grafts are obtained from a new donor site. In our department, the surplus cartilages obtained during primary rhinoplasties of the patients who are thought to be probable secondary rhinoplasty candidates are stored in a postauricular pocket after their volumes are measured and marked down. In the secondary operations the volume of the grafts are measured again and the grafts are used. We have found out that there is no significant difference between the initial and secondary volumes of lower lateral cartilages (3.6% of initial volume is lost), but the difference between the initial and secondary volumes of septal cartilages is significant (6.9% of initial volume is lost), and the stored cartilages are sufficient qualitatively and quantitatively for the secondary rhinoplasties.     

I-Cell disease,mucolipidosis II

Pathological, histochemical, ultrastructural and biochemical studies on 4 cases of I-cell disease are reported. These studies support a lysosomal defect with deficiency of many acid hydrolases and storage of both glycolipids and mucopolysaccharides within lysosomes. The clinical, pathological and biochemical spectra of I-cell disease in these 4 cases suggest three distinct nosologic entities: a prototype, a malignant infantile form and a more benign juvenile type. Consanguinity was present in one of the cases. An autosomal recessive mode of inheritance seems most likely.Supported in part by NIH Grants GM 08217, GM 15422, 5 KO4 HD 18982, HD 04583, and 06426, by a Grant from The National Foundation—March of Dimes and by Grant Sp 63/2 of the Deutsche Forschungsgemeinschaft. Contributed in part, as paper No. 1587 from the University of Wisconsin Genetics Laboratory.